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Research & Projects

Discover our research, conference presentations, and ongoing collaborative projects advancing critical care through CLIF

Publications

A common longitudinal intensive care unit data format (CLIF) for critical illness research

Conference Presentations

ATS 2025 Conference

American Thoracic Society (ATS)

2025 Multiple CLIF studies presented

Research Presentations:

Electronic health record signatures of spontaneous awakening trials

Multi-center analysis of sedation cessation patterns in mechanically ventilated patients

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Multi-center evaluation of prone positioning practices

For moderate and severe hypoxemic respiratory failure

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Association of sex and height with low-tidal volume ventilation

Multi-center cohort of critically ill adults

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CLIF respiratory support waterfall methodology

Novel method for analyzing ventilator mode patterns in critical care

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ATS 2024 Conference

American Thoracic Society (ATS)

2024 Various CLIF studies presented

Research Presentations:

Advancing multi-center clinical research in critically ill patients

Through the development of a common longitudinal ICU format (CLIF)

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Early mobilization opportunity windows

Multi-center comparative analysis of clinical trial and consensus guideline eligibility criteria

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Variation in setting low tidal volume ventilation on day 1

Analysis of mechanical ventilation practices by hospital

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AMIA 2024 CLIF Presentation

American Medical Informatics Association (AMIA)

2024 Informatics Summit

Kaveri Chhikara presents the CLIF at the AMIA Summit, touching on the standardized data format created to address challenges in using ICU electronic health record data for research.

Ongoing Projects

The CLIF consortium is a network of NIH funded investigators.

Principal Investigators (PIs) in the consortium are supported by a wide range of NIH grants that use big data and advanced ML techniques to answer open scientific questions related to critical illness. Each of these projects would be better with CLIF rather than done in silos.

Improving the efficiency and equity of critical care allocation during a crisis with place-based disadvantage indices

CLIF Project: Creating a life support allocation triage score for crisis standards of care
PI: William Parker, University of Chicago

Identifying Areas to Improve ICU Outcomes through Provider Variation

CLIF Project: Studying hospital variation in low-tidal volume ventilation across hospital systems
PI: Nicholas Ingraham, University of Minnesota

Identification of Precision Sepsis Subphenotypes Using Vital Sign Trajectories

CLIF Project: Validating the association of temperature trajectories and ICU mortality across hospital systems
PI: Sivasubramanium Bhavani, Emory University

Sustainable Implementation of Prone Positioning for the Acute Respiratory Distress Syndrome

CLIF Project: Studying the association between proning practice patterns and ARDS survival
PI: Chad Hochberg, John Hopkins University

Early Mobilization: Operationalizing Big Data & Implementation Science to Lead Expansion to ICUs (E-MOBILE-ICU)

CLIF Project: Identifying critically ill patients who are eligible for mobilization using the electronic healthcare record
PI: Bhakti Patel, University of Chicago

Machine learning to predict cure in severe pneumonia episodes

CLIF Project: Prediction of severe pneumonia using machine learning
PI: Catherine Gao, Northwestern University

SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and Technology

CLIF Project: Develop an oncology-specific sepsis prediction model using EHR data and human-centered design
PI: Patrick Lyons, Oregon Health and Science University