Research & Projects
Discover our research, conference presentations, and ongoing collaborative projects advancing critical care through CLIF
Publications
Federation, Not Centralization: A New Paradigm for EHR-Based Critical Care Research
Prone Positioning in a North American Cohort of Hypoxemic Patients on Mechanical Ventilation
The Epidemiology of ICU Readmissions Across Ten Health Systems
Correspondence on "A common longitudinal intensive care unit data format (CLIF) for critical illness research" - Author's reply
A common longitudinal intensive care unit data format (CLIF) for critical illness research
Conference Presentations
American Thoracic Society (ATS)
CLIF Consortium investigators gathered at the ATS 2026 International Conference, presenting a broad slate of multicenter critical-care studies built on the Common Longitudinal ICU data Format.
Research Presentations:
Comparing Cross-Site Validation, Transfer Learning, and Independent Training for ICU Mortality Prediction: A U.S. Multicenter Study
Personalized Respiratory Support for Acute Respiratory Failure Using Deep Reinforcement Learning
Patient Preferred Language and Continuous Neuromuscular Blockade During Invasive Mechanical Ventilation: A Multicenter Retrospective Cohort Study
Differential Severity Classification and Prognostic Performance of PaO2/FIO2 Versus SpO2/FIO2 Ratios in Adults With Acute Hypoxemic Respiratory Failure
Redefining White Blood Cell and Temperature Thresholds for Sepsis Detection: A Multicenter, Data-Driven Analysis
Cumulative Air Pollution Exposure Increases the Severity of Acute Respiratory Failure: A U.S. Multicenter Study
Diurnal and Institutional Variation in Sedation and Extubation in Mechanical Ventilation: A Multicenter Study of Six Hospital Systems
The Epidemiology of Hospital Code Status Designations Across Six US Health Systems
A Location Agnostic EHR Definition of Critical Illness Using the Common Longitudinal ICU Data Format (CLIF)
Clinical Effects of a Nationwide IV Fluid Shortage on Patients With Sepsis in an Academic Health System
Intermediate Versus Intensive Care for Patients With Moderate-Severe Acute Respiratory Failure
Characteristics and Outcomes of ED Patients Requiring Non-invasive Respiratory Support Admitted to Different Levels of Care
Heterogeneous Longitudinal Trajectories of Antibiotic Spectrum Coverage in Critically Ill Adults: A Multicenter Study of 9 U.S. Healthcare Systems
Trends in Multidrug-resistant Pseudomonas Aeruginosa in ICU Patients Across U.S. Healthcare Systems, 2018-2024
Society of Critical Care Medicine (SCCM)
CLIF investigators presented at the SCCM 2026 Critical Care Congress — sharing work on EHR-based phenotyping of spontaneous awakening and breathing trials and introducing the Common Longitudinal ICU data Format to the critical-care community.
Research Presentations:
Multicenter Study on Continuous Renal Replacement Therapy Timing and Intensity in ICU Patients
Phenotyping Spontaneous Awakening and Breathing Trials in the Electronic Health Record
Duration and Predictors of Prolonged Respiratory Failure in 19,444 Mechanically Ventilated Patients
American Medical Informatics Association (AMIA)
CLIF Consortium members led a hands-on workshop at the AMIA Amplify 2026 Informatics Conference, teaching attendees how to train reinforcement learning models on CLIF-formatted ICU data.
CLIF Meets RL: A Hands-On Workshop on Training Reinforcement Learning Models with Common Longitudinal ICU Format (CLIF) Data
Hands-on workshop — Kaveri Chhikara, Saki Amagai, and Yikuan Li.
Symposium on Artificial Intelligence for Learning Health Systems (SAIL)
CLIF investigators presented a federated, privacy-preserving evaluation of ICU clinical decision support spanning eight U.S. health systems at SAIL 2026.
Privacy-Preserving Multicenter Evaluation of ICU Clinical Decision Support: A Federated Framework Across Eight U.S. Health Systems
Poster — Juan Rojas and Vaishvik Chaudhari.
American Thoracic Society (ATS)
Research Presentations:
Electronic health record signatures of spontaneous awakening trials
Multi-center analysis of sedation cessation patterns in mechanically ventilated patients
View Abstract →Multi-center evaluation of prone positioning practices
For moderate and severe hypoxemic respiratory failure
View Abstract →Association of sex and height with low-tidal volume ventilation
Multi-center cohort of critically ill adults
View Abstract →CLIF respiratory support waterfall methodology
Novel method for analyzing ventilator mode patterns in critical care
View Abstract →
American Thoracic Society (ATS)
Research Presentations:
Advancing multi-center clinical research in critically ill patients
Through the development of a common longitudinal ICU format (CLIF)
View Abstract →Early mobilization opportunity windows
Multi-center comparative analysis of clinical trial and consensus guideline eligibility criteria
View Abstract →Variation in setting low tidal volume ventilation on day 1
Analysis of mechanical ventilation practices by hospital
View Abstract →
American Medical Informatics Association (AMIA)
Kaveri Chhikara presents the CLIF at the AMIA Summit, touching on the standardized data format created to address challenges in using ICU electronic health record data for research.
Ongoing Projects
The CLIF consortium is a network of NIH funded investigators.
Principal Investigators (PIs) in the consortium are supported by a wide range of NIH grants that use big data and advanced ML techniques to answer open scientific questions related to critical illness. Each of these projects would be better with CLIF rather than done in silos.